2026-02-24
GLP-1 Agonists and Aging: Metabolic Benefits, Cardiovascular Evidence, and Longevity Implications
GLP-1 receptor agonists like semaglutide have demonstrated cardiovascular and metabolic benefits beyond weight reduction. This review covers the mechanistic basis, major trial evidence, and the open questions about their role in longevity medicine.
2026-02-22
Anemia and Iron Deficiency in Aging: Diagnosis, Causes, and Supplementation Evidence
Anemia affects 10–20% of adults over 65 and is independently associated with frailty, cognitive decline, and mortality. Iron deficiency is the most common cause but is often missed in older adults. Supplementation restores function when deficiency is confirmed — but iron excess is harmful and routine supplementation without deficiency is not indicated.
2026-02-21
Dehydration in Aging: Why Thirst Fails and How to Stay Ahead of It
Thirst sensitivity declines with age, making chronic underhydration common and underrecognized. This article covers the physiological changes that increase dehydration risk and the evidence-based strategies to counter them.
2026-02-21
Gut Microbiome and Probiotics in Aging: Diversity Decline, Leaky Gut, and Evidence-Based Interventions
The gut microbiome undergoes progressive diversity loss with age — a pattern linked to increased intestinal permeability, systemic inflammation, and reduced short-chain fatty acid production. Dietary fiber, fermented foods, and targeted probiotics have the best evidence for reversing these changes.
2026-02-20
Constipation and Low Fiber Intake: Psyllium, Inulin, and Probiotic Evidence
Guideline-aligned constipation care starts with fiber and hydration strategy. Psyllium has the strongest direct bowel evidence, while inulin and selected probiotics can add context-specific support.