NAD+ precursor and lipid metabolism
GradeANiacin (Vitamin B3)
Niacin is a direct NAD+ precursor and has decades of evidence for raising HDL and lowering triglycerides. AIM-HIGH and HPS2-THRIVE trials showed cardiovascular benefit over statins was not additive. NAD+ elevation is dose-dependent.
Dose
50-500 mg for NAD+ support; 1000-2000 mg for lipids (medical use)
Open profile →Inflammation resolution and cardiovascular health
GradeAOmega-3 Fatty Acids
EPA and DHA omega-3 fatty acids have robust evidence for triglyceride reduction, cardiovascular risk in high-risk populations (REDUCE-IT), anti-inflammatory effects, and brain support. VITAL trial showed modest benefit in non-high-risk populations.
Timing
With meals to improve absorption and reduce fishy aftertaste
Open profile →LDL cholesterol reduction
GradeAPlant Sterols (Phytosterols)
Plant sterols and stanols reduce LDL cholesterol by blocking intestinal cholesterol absorption. Meta-analyses show consistent 7-10% LDL reduction at 2 g/day. FDA permits a health claim for this effect.
Dose
2 g (as sterols or stanols)
Timing
With meals that contain dietary fat
Open profile →Cholesterol reduction and gut health
GradeAPsyllium Fiber
Psyllium husk is a soluble fiber with FDA-approved health claims for heart disease risk reduction via LDL cholesterol lowering. Meta-analyses confirm 5-7% LDL reduction. Also improves glycemic control and gut transit.
Dose
7-10 g (about 1 tablespoon)
Timing
Before meals with large amounts of water
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