2026-02-20
Arterial Stiffness Risk: Cocoa Flavanols, Aged Garlic, Olive Leaf, and Beetroot
Aerobic training and blood-pressure control remain primary for arterial stiffness. Cocoa flavanols, aged garlic, olive leaf, and beetroot may provide modest vascular support.
2026-02-18
POLYCAD Trial: Spermidine Supplementation in Coronary Artery Disease — Design and Interim Context
The POLYCAD trial is testing 24 mg/day spermidine in 187 older adults with coronary artery disease for 48 weeks. Trial completion is expected August 2026 — no efficacy results exist yet. Prior cohort data from Eisenberg et al. 2016 provides the rationale.
2026-02-10
Resveratrol Protocols in Longevity Clinics: Evidence, Dosing, and Safety Context
How longevity clinics structure resveratrol protocols and what current human evidence does and does not support.
2026-02-07
Nitric Oxide and Vascular Health: Beetroot, Citrulline, and Aged Garlic — Evidence Review
Nitric oxide (NO) production declines with age, contributing to arterial stiffness, reduced exercise capacity, and cardiovascular risk. Beetroot nitrate, citrulline, and aged garlic work through complementary NO-enhancing pathways. Stacking them is rational and supported by independent trial evidence.
2026-01-22
Arterial Stiffness Interventions: Cocoa Flavanols, Nitrates, Aged Garlic, and RCT Outcomes
Arterial stiffness (measured as pulse wave velocity) is an independent cardiovascular risk factor that increases with age. Cocoa flavanols, dietary nitrates, and aged garlic extract each show significant reductions in RCTs. Lifestyle factors (exercise, sodium restriction) remain foundational.