2026-02-19
Apigenin and Sleep: Evidence, Mechanisms, and Protocol
Apigenin is being studied for sleep support through GABA-related pathways, with early human data suggesting possible modest benefits and a generally favorable short-term tolerability profile.
2026-02-11
Circadian Rhythm and Longevity: Disruption Effects, Melatonin, and Timed Supplementation
Circadian disruption — from shift work, artificial light, and irregular sleep — accelerates biological aging and increases disease risk. Melatonin, light hygiene, and chronobiologically timed supplement dosing (e.g., resveratrol at night) may partially mitigate disruption effects.
2026-02-09
Apigenin: CD38 Inhibition, NAD+ Preservation, and Sleep Evidence
Apigenin inhibits CD38, an enzyme that consumes NAD+ — positioning it as an indirect NAD booster. It also has mild sleep-promoting and senolytic properties. Human evidence is limited but mechanistic rationale is solid.
2026-02-04
Sleep Optimization Beyond Melatonin: Magnesium, Apigenin, CBT-I, and Light Hygiene
Melatonin is one of many sleep tools. Magnesium glycinate, apigenin (chamomile extract), and glycine have separate evidence bases. Cognitive-behavioral therapy for insomnia (CBT-I) outperforms all supplements for chronic insomnia. Combining behavioral and supplement approaches is rational.
2026-01-30
Melatonin Beyond Sleep: Antioxidant Role, Circadian Health, and Mitochondrial Protection in Aging
Melatonin production declines with age, affecting not just sleep but also circadian gene regulation, mitochondrial antioxidant defense, and neuroinflammation. Evidence is strongest for sleep; antioxidant and longevity roles are plausible but less clinically established.