2026-02-24
Skin Aging and Photoaging: Mechanisms, UV Damage, and Evidence-Based Interventions
Skin aging involves intrinsic (chronological) and extrinsic (UV-driven photoaging) components. UV radiation is responsible for approximately 80% of visible facial aging. Topical retinoids have the strongest evidence base for reversing photoaging signs. Oral collagen peptides have emerging RCT evidence for skin hydration and elasticity. Sun protection remains the highest-impact preventive intervention.
2026-02-24
Joint Health and Cartilage Support: What the Evidence Shows
Cartilage has limited self-repair capacity, but several interventions modestly slow degradation and reduce symptoms. Here is what the clinical evidence supports for joint health in aging.
2026-02-21
Longevity Protocol for Women Over 50: Evidence-Based Priorities
Perimenopause and post-menopause mark a major metabolic and hormonal inflection point. This protocol covers the highest-leverage interventions for women over 50, grounded in current evidence.
2026-02-19
Glucosamine for Joints: Cartilage Evidence, Cardiovascular Signal, and Sulfate vs Hydrochloride
Glucosamine sulfate has modest RCT evidence for slowing cartilage loss and reducing joint pain in knee osteoarthritis. An unexpected but consistent epidemiological signal links glucosamine use with lower cardiovascular mortality — the mechanism may involve AMPK activation.
2026-02-18
Dasatinib and Quercetin for Senolytic Therapy: Mayo Clinic Phase 2 Trial Findings
A Mayo Clinic Phase 2 trial tested dasatinib plus quercetin in 60 older women with low bone density, finding improved bone formation markers. Dasatinib is an FDA-approved cancer drug requiring physician supervision.