Best Fit Profiles
- homocysteine reduction, DNA methylation support, MTHFR variant individuals
Methylation, homocysteine reduction, and DNA repair
Folate (Vitamin B9)
Folate is essential for one-carbon metabolism, DNA methylation, and homocysteine clearance. Deficiency is strongly associated with elevated homocysteine and cardiovascular risk. MTHFR variants affect conversion efficiency of folic acid to active methylfolate.
Evidence Level A
Evidence and Risk Labels
Evidence A/B/C reflects research maturity, and risk levels reflect monitoring needs. These labels support comparison, not diagnosis or treatment decisions.
See full scoring guideClinical Snapshot
- Effect Size
- Large in deficiency; meaningful homocysteine reduction in hyperhomocysteinemia; modest in replete individuals
- Safety
- Low Risk
High-dose folic acid can mask B12 deficiency; prefer methylfolate (5-MTHF) in MTHFR C677T carriers. Avoid very high doses without monitoring.
Research Dosing
This reflects common ranges and protocols used in published studies, not personal medical advice.
- Typical Daily Dose
- 400-800 mcg (as methylfolate preferred)
- Timing
- With meals
- Protocol Duration in Studies
- Ongoing; part of B-complex protocol
MTHFR variant individuals should use methylfolate form, not folic acid.