Best Fit Profiles
- cognitive support and anxiety management, particularly when systemic magnesium is already adequate
Brain magnesium levels and cognitive function
Magnesium L-Threonate
Magnesium L-threonate (Magtein) crosses the blood-brain barrier more effectively than other magnesium forms, increasing brain magnesium levels. Animal studies show improved synaptic plasticity. Human RCTs show modest cognitive improvements and anxiety reduction.
Evidence Level B
Evidence and Risk Labels
Evidence A/B/C reflects research maturity, and risk levels reflect monitoring needs. These labels support comparison, not diagnosis or treatment decisions.
See full scoring guideClinical Snapshot
- Effect Size
- Modest cognitive improvement and anxiety reduction in human trials; superior brain penetration vs other forms
- Safety
- Low Risk
More expensive than other magnesium forms; some experience vivid dreams or mild drowsiness initially. Read elemental magnesium dosing carefully.
Research Dosing
This reflects common ranges and protocols used in published studies, not personal medical advice.
- Typical Daily Dose
- 1.5-2 g (providing ~144 mg elemental magnesium)
- Timing
- Evening or split morning/evening
- Protocol Duration in Studies
- 8-12 weeks minimum for cognitive endpoints
Magtein is the proprietary form from MIT research; other L-threonate products are generic. Research doses expressed as total compound weight, not elemental magnesium.