2026-02-24
Skin Aging and Photoaging: Mechanisms, UV Damage, and Evidence-Based Interventions
Skin aging involves intrinsic (chronological) and extrinsic (UV-driven photoaging) components. UV radiation is responsible for approximately 80% of visible facial aging. Topical retinoids have the strongest evidence base for reversing photoaging signs. Oral collagen peptides have emerging RCT evidence for skin hydration and elasticity. Sun protection remains the highest-impact preventive intervention.
2026-02-18
NMN vs NR vs Nicotinamide: First Direct Human Comparison of NAD+ Precursors
A 2025 Nature Metabolism crossover trial directly compared NMN, NR, and nicotinamide in healthy adults. NMN and NR produced sustained blood NAD+ increases of 130–150%; nicotinamide produced only a transient 4-hour rise. Gut microbiome conversion was a key mechanistic finding.
2026-02-17
SIRT3 Activators in Early Clinical Development: Mitochondrial Targets for Aging
SIRT3 is a mitochondrial deacetylase linked to energy efficiency and oxidative stress resistance. Novel small-molecule SIRT3 activators are in preclinical development; human efficacy data does not yet exist.
2026-02-17
NAD+ Precursor Supplementation and Cognitive Fatigue: Mechanism and Human Evidence
NAD+ precursors reliably elevate blood NAD+ in humans and activate mitochondrial energy pathways. Whether this translates to clinically meaningful reductions in cognitive fatigue requires larger, longer trials.
2026-02-10
Nicotinamide Riboside and Nicotinamide: NAD+ Precursor Comparison and Human Trial Evidence
Nicotinamide riboside (NR) and plain nicotinamide both raise NAD+ but through different pathways and with different safety profiles. NR has more published human trials; nicotinamide is cheaper but raises sirtuin-inhibition concerns at high doses.