2026-02-18
CoQ10 and Mitochondrial Function: Age-Related Decline and Clinical Evidence
CoQ10 declines with age and statin exposure. Human evidence is strongest in heart failure and statin-associated muscle symptoms, while prevention use in healthy adults remains less certain.
2026-02-17
SIRT3 Activators in Early Clinical Development: Mitochondrial Targets for Aging
SIRT3 is a mitochondrial deacetylase linked to energy efficiency and oxidative stress resistance. Novel small-molecule SIRT3 activators are in preclinical development; human efficacy data does not yet exist.
2026-02-08
Mitochondria and Aging: Bioenergetics, ROS, Fission/Fusion Dynamics, and Intervention Targets
Mitochondrial dysfunction is a central hallmark of aging. ATP production efficiency declines, ROS production increases, and the balance of fission (fragmentation) and fusion (elongation) shifts unfavorably. This article explains the biology and maps interventions — from CoQ10 to urolithin A — to specific mitochondrial nodes.
2026-02-05
Mitochondrial Health Stack: CoQ10, PQQ, Carnitine, ALA, and Urolithin A — Synergies and Evidence
A comprehensive mitochondrial support protocol addresses electron transport (CoQ10), fatty acid transport (carnitine), biogenesis (PQQ, urolithin A), and antioxidant protection (ALA). Each supplement addresses a different node in mitochondrial biology. Stacking rationale is strong, though direct synergy evidence in humans is limited.
2026-01-28
Lion
Lion's mane (Hericium erinaceus) contains hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis. Human trials show improvements in mild cognitive impairment, though optimal extract form and dose are still being established.