2026-02-24
Air Pollution, Oxidative Stress, and Nutritional Protection
Air pollution is a top-5 global health risk. While environmental mitigation is primary, nutritional strategies can blunt some of the inflammatory and oxidative damage from particulate and ozone exposure.
2026-02-17
Caloric Restriction Mimetics in 2025: Multi-Pathway Geroprotectors Under Clinical Evaluation
A 2025 Biogerontology review maps geroprotective compounds targeting AMPK, mTOR, and autophagy pathways. Most remain at biomarker endpoints; hard longevity data in humans is largely absent.
2026-02-17
SIRT3 Activators in Early Clinical Development: Mitochondrial Targets for Aging
SIRT3 is a mitochondrial deacetylase linked to energy efficiency and oxidative stress resistance. Novel small-molecule SIRT3 activators are in preclinical development; human efficacy data does not yet exist.
2026-02-11
Longevity Gene Activation: SIRT1, AMPK, mTOR, and NRF2 — Compound-by-Compound Evidence Map
Four gene networks — SIRT1 (longevity deacetylase), AMPK (energy sensor), mTOR (growth regulator), and NRF2 (antioxidant response) — are the primary longevity targets for supplement intervention. This article maps which compounds activate which genes, the quality of evidence, and where interactions become relevant.
2026-01-23
Sulforaphane and NRF2: Broccoli Sprout Extract, Detoxification, and Cancer Prevention Evidence
Sulforaphane is the most potent food-derived NRF2 activator. Broccoli sprout extract concentrates glucoraphanin (sulforaphane precursor) while myrosinase is needed for conversion. Clinical evidence for cancer chemoprevention and detoxification support is emerging.