2026-02-24
Heat Stress and Aging: Why Older Adults Are More Vulnerable and How to Adapt
Thermoregulatory capacity declines with aging: sweating onset is delayed, cardiovascular reserve is reduced, and thirst is blunted. This article covers why older adults face higher heat mortality risk and what evidence supports safe heat adaptation.
2026-02-24
Orthostatic Intolerance in Aging: Causes, Risks, and Evidence-Based Management
Orthostatic intolerance — dizziness or near-fainting upon standing — affects up to 20% of adults over 65 and substantially increases fall risk. This article reviews the mechanisms and evidence-based management strategies.
2026-02-21
Dehydration in Aging: Why Thirst Fails and How to Stay Ahead of It
Thirst sensitivity declines with age, making chronic underhydration common and underrecognized. This article covers the physiological changes that increase dehydration risk and the evidence-based strategies to counter them.
2026-02-18
POLYCAD Trial: Spermidine Supplementation in Coronary Artery Disease — Design and Interim Context
The POLYCAD trial is testing 24 mg/day spermidine in 187 older adults with coronary artery disease for 48 weeks. Trial completion is expected August 2026 — no efficacy results exist yet. Prior cohort data from Eisenberg et al. 2016 provides the rationale.
2026-02-18
CoQ10 and Mitochondrial Function: Age-Related Decline and Clinical Evidence
CoQ10 declines with age and statin exposure. Human evidence is strongest in heart failure and statin-associated muscle symptoms, while prevention use in healthy adults remains less certain.