Best Fit Profiles
- methylation-focused lab-driven protocols
Methylation and homocysteine support
Trimethylglycine (TMG)
TMG reliably lowers homocysteine; the clinical payoff depends on baseline risk profile and overall B-vitamin status.
Evidence Level B
Evidence and Risk Labels
Evidence A/B/C reflects research maturity, and risk levels reflect monitoring needs. These labels support comparison, not diagnosis or treatment decisions.
See full scoring guideClinical Snapshot
- Effect Size
- Reliable homocysteine reduction with context-dependent downstream benefit
- Safety
- Low Risk
Should be paired with B-vitamin context in elevated homocysteine protocols.
Research Dosing
This reflects common ranges and protocols used in published studies, not personal medical advice.
- Typical Daily Dose
- 500-3000 mg
- Timing
- Once or twice daily with meals
- Protocol Duration in Studies
- 4-12 weeks before reassessing homocysteine markers
Dose selection is usually individualized to baseline homocysteine and B-vitamin status.