2026-02-24
Recurrent UTIs in Aging: Prevention Strategies Beyond Antibiotics
Recurrent urinary tract infections are common in older adults, particularly post-menopausal women, and lead to significant antibiotic overuse. This article covers evidence-based prevention strategies including d-mannose, cranberry, and vaginal microbiome support.
2026-02-24
Skin Aging and Photoaging: Mechanisms, UV Damage, and Evidence-Based Interventions
Skin aging involves intrinsic (chronological) and extrinsic (UV-driven photoaging) components. UV radiation is responsible for approximately 80% of visible facial aging. Topical retinoids have the strongest evidence base for reversing photoaging signs. Oral collagen peptides have emerging RCT evidence for skin hydration and elasticity. Sun protection remains the highest-impact preventive intervention.
2026-02-24
Testosterone Decline in Men: Natural Trajectory, Functional Impact, and Evidence-Based Support
Testosterone declines approximately 1-2% per year from age 30. The clinical significance of this decline depends on absolute levels and symptoms, not chronological age alone. Testosterone replacement therapy has RCT evidence for improving muscle mass, bone density, and sexual function in men with confirmed hypogonadism. Lifestyle factors significantly modify the trajectory.
2026-02-24
Testosterone Decline in Aging Men: Natural Interventions, Monitoring, and TRT Context
Testosterone declines ~1% per year after age 30 in men. Below clinical thresholds, symptoms include fatigue, sarcopenia, and cognitive fog. Lifestyle interventions (resistance training, sleep, zinc, vitamin D) have the best evidence for supporting endogenous production. Ashwagandha and fenugreek show modest RCT data.
2026-02-24
Vision and Age-Related Macular Degeneration: Lutein, Zeaxanthin, and AREDS2 Evidence
The AREDS2 trial established lutein and zeaxanthin as replacements for beta-carotene in the AMD supplement formula, reducing progression risk by 25% in high-risk eyes. Dietary intake from dark leafy greens provides equivalent carotenoids. This article explains what the evidence supports and what it does not.