Feb 24, 2026Longevity Biomarkers: What to Test, What the Results Mean, and How to Track ProgressBiological age testing spans conventional labs (HbA1c, CRP, lipids) to newer epigenetic clocks and proteomic aging scores. Most conventional biomarkers are actionable today; epigenetic clocks measure biological vs. chronological age but their clinical utility for intervention-guiding remains limited. A pragmatic panel of validated tests provides meaningful signal about longevity trajectory.
Feb 24, 2026Longevity Biomarkers: What to Track, How Often, and What the Evidence Says They MeanNo single biomarker captures biological age, but a panel of accessible blood and functional markers — HbA1c, hs-CRP, homocysteine, IGF-1, DHEA-S, grip strength, and VO2 max — provides a practical composite picture. Epigenetic clocks offer precision but limited actionability at current cost.
Feb 9, 2026Calcium Alpha-Ketoglutarate and Epigenetic Aging: Biological Age Reduction EvidenceCalcium alpha-ketoglutarate (Ca-AKG) is an intermediate in the Krebs cycle and an alpha-ketoglutarate-dependent dioxygenase co-factor critical for epigenetic regulation. A clinical trial showed an 8-year reduction in biological age by DNA methylation clock. Evidence is early but striking.
Feb 9, 2026Epigenetic Clocks and Biological Age: Horvath, GrimAge, DunedinPACE — What They MeasureEpigenetic clocks measure DNA methylation patterns that change predictably with age. Different clocks predict different endpoints — Horvath measures biological age, GrimAge predicts mortality, DunedinPACE measures aging speed. Understanding what they do and don't measure is essential before acting on results.