Feb 13, 2026Omega-3 Fatty Acids: EPA, DHA, Cardiovascular Outcomes, and Cognitive Aging EvidenceEPA and DHA are the two clinically relevant omega-3 fatty acids. High-dose EPA (REDUCE-IT trial, 4 g/day icosapentaenoic acid) significantly reduced cardiovascular events. DHA drives brain structural benefits. Standard fish oil doses produce modest effects; high-dose prescription forms show stronger outcomes.