Feb 8, 2026Epigenetic Reprogramming: Yamanaka Factors, Partial OSK Reprogramming, and the Clinical HorizonPartial epigenetic reprogramming using OSK (Oct4, Sox2, Klf4) Yamanaka factors has reversed multiple aging hallmarks in animal models without inducing cancer. Human translation is in early clinical development. This article explains the biology, current trials, and realistic timeline.