Feb 24, 2026Senolytics and Cellular Senescence: Mechanisms, Mayo Clinic Evidence, and Clinical StatusSenolytics are drugs and compounds that selectively clear senescent cells, which accumulate with age and drive chronic inflammation. This review covers the mechanisms, the Mayo Clinic dasatinib+quercetin trials, fisetin evidence, and the current clinical status.
Feb 19, 2026Fisetin and Senolytic Research: Human Data, Protocol Context, and LimitationsFisetin has a strong preclinical senolytic rationale, while human evidence remains early-stage with limited placebo-controlled outcome data.
Feb 3, 2026Fisetin as a Senolytic: Zombie Cell Clearance, Mayo Clinic Data, and Dosing EvidenceFisetin is the most potent natural senolytic identified in preclinical studies. The Mayo Clinic demonstrated senescent cell clearance in human adipose tissue. Clinical protocols use intermittent high-dose cycles. Human evidence is early but promising.