Feb 24, 2026Gut Barrier Integrity in Aging: Intestinal Permeability, Inflammaging, and SupportAge-related increases in intestinal permeability ("leaky gut") allow bacterial products including lipopolysaccharide (LPS) to enter systemic circulation, driving chronic low-grade inflammation associated with multiple aging-related conditions. Evidence-based interventions include dietary fiber, fermented foods, and specific probiotics — though research on reversing permeability changes in older humans is in early stages.
Feb 24, 2026Inflammaging: Chronic Low-Grade Inflammation in Aging, Causes, and Intervention EvidenceInflammaging — the chronic low-grade inflammatory state that accumulates with age — is now recognized as a driver of virtually every major age-related disease. Senescent cells, gut dysbiosis, and visceral fat are the primary sources. Targeted interventions address the root causes, not just the biomarkers.