Feb 11, 2026Circadian Rhythm and Longevity: Disruption Effects, Melatonin, and Timed SupplementationCircadian disruption — from shift work, artificial light, and irregular sleep — accelerates biological aging and increases disease risk. Melatonin, light hygiene, and chronobiologically timed supplement dosing (e.g., resveratrol at night) may partially mitigate disruption effects.
Jan 30, 2026Melatonin Beyond Sleep: Antioxidant Role, Circadian Health, and Mitochondrial Protection in AgingMelatonin production declines with age, affecting not just sleep but also circadian gene regulation, mitochondrial antioxidant defense, and neuroinflammation. Evidence is strongest for sleep; antioxidant and longevity roles are plausible but less clinically established.