Feb 15, 2026Silymarin (Milk Thistle): Liver Protection, MASLD Evidence, and Bioavailability ChallengesSilymarin (the active complex of milk thistle) has antioxidant and anti-inflammatory effects on hepatocytes. Evidence supports modest liver enzyme reduction in MASLD, though poor water solubility limits standard extract absorption. Phytosome forms show better bioavailability.