Feb 24, 2026Zone 2 Training and Mitochondrial Health: Evidence for Endurance, Metabolic, and Longevity BenefitsZone 2 training — sustained low-intensity aerobic work — is the primary stimulus for mitochondrial biogenesis and fat oxidation capacity. This review covers how to define and perform zone 2, the evidence for its health and longevity benefits, and how it fits into a complete training program.