Feb 24, 2026Polyphenol Stack Synergy: Quercetin, Resveratrol, Curcumin, and EGCG Combined EvidenceQuercetin, resveratrol, curcumin, and EGCG activate overlapping pathways — NRF2, SIRT1, AMPK, and NFkB inhibition. Stacking them is popular but evidence for synergistic human benefit is largely extrapolated from in vitro and animal models. This article assesses what stacking adds and what it does not.
Feb 20, 2026Arterial Stiffness Risk: Cocoa Flavanols, Aged Garlic, Olive Leaf, and BeetrootAerobic training and blood-pressure control remain primary for arterial stiffness. Cocoa flavanols, aged garlic, olive leaf, and beetroot may provide modest vascular support.
Feb 19, 2026Polyphenol Protocols in Cognition Clinics: Clinical Context and Evidence LimitsResveratrol, quercetin, and fisetin are used in some cognition-focused protocols, but human evidence is mixed and best interpreted as adjunctive support rather than primary therapy.
Feb 4, 2026Resveratrol and SIRT1: Longevity Pathway Activation, Human Trial Disappointments, and ContextResveratrol activated enormous interest as a SIRT1 activator after early animal data. Human trials have been largely disappointing for longevity endpoints. Benefits in specific metabolic contexts (glucose tolerance, inflammation) are more supported. Understanding the gap between mechanism and human outcome is essential.