Feb 11, 2026Pterostilbene vs Resveratrol: Bioavailability, Sirtuin Activation, and Evidence ComparisonPterostilbene is a methylated resveratrol analog with substantially better oral bioavailability. It activates SIRT1 and AMPK, lowers blood pressure in some trials, but has fewer published human studies than resveratrol. The trade-off between bioavailability and evidence depth is real.