Feb 14, 2026Supplement Cycling Protocols: Rapamycin, Senolytics, and Adaptogens — Evidence for Intermittent UseNot all supplements should be taken daily. Rapamycin is typically dosed weekly to preserve mTOR signaling windows. Senolytics (dasatinib + quercetin, fisetin) are used in short intermittent bursts. Even some adaptogens are cycled to prevent tolerance. This article maps the rationale and evidence for each.