Feb 17, 2026Astragalus and TA-65: Telomerase Activation, Immune Aging, and Evidence LimitsAstragalus extract (specifically cycloastragenol/TA-65) is the only commercially available small molecule with credible telomerase activation evidence in humans. Effects on telomere length are small and inconsistent. Immune aging benefits are better supported.
Feb 10, 2026Telomere Biology and Aging: Attrition Rate, Telomerase, and What Supplements ShowTelomeres shorten with each cell division, and critically short telomeres trigger senescence or apoptosis. Telomerase can extend them but its activation is complex and cancer-relevant. This article covers the biology, what supplements like vitamin D and astragalus show, and honest limitations.
Feb 9, 2026Gene Therapy for Aging: Telomerase Activation, AAV Delivery, Current Trials, and RisksGene therapy to extend healthspan is moving from animal studies to human trials. Telomerase activation via AAV delivery extended lifespan in mice. Human applications are in early development. The risks — including oncogenic potential — are significant and must be understood clearly.