2026-02-24
SIRT3 and Mitochondrial Integrity: NAD-Dependent Deacetylase, Caloric Restriction Mimicry, and Activators
SIRT3 is the primary mitochondrial sirtuin — a NAD-dependent deacetylase that regulates ATP synthesis, ROS detoxification, and fatty acid oxidation. Its activity declines with age and NAD+ depletion. Activators include honokiol, urolithin A, and exercise, though human trial data is thin.
2026-02-24
Alcohol, Aging, and Long-Term Health: What the Evidence Shows
Alcohol consumption interacts with aging biology in complex ways. This article covers the liver, brain, cardiovascular, and cancer evidence, plus what nutritional strategies can mitigate harm.
2026-02-24
Air Pollution, Oxidative Stress, and Nutritional Protection
Air pollution is a top-5 global health risk. While environmental mitigation is primary, nutritional strategies can blunt some of the inflammatory and oxidative damage from particulate and ozone exposure.
2026-02-24
Circadian Rhythm Disruption in Aging: Mechanisms, Health Consequences, and Restoration
Circadian clocks govern virtually every physiological process — metabolism, immune function, DNA repair, and hormone secretion follow 24-hour rhythms entrained by light. With aging, the circadian system weakens: clock gene amplitude declines, light sensitivity decreases, and circadian outputs desynchronize. Strengthening circadian inputs through light exposure, meal timing, and physical activity has evidence-based effects on sleep, metabolic health, and biological aging.
2026-02-24
Cognitive Stress Reactivity: How Stress Disrupts Mental Performance and What to Do About It
Repeated psychological stress impairs working memory, attention, and decision-making through cortisol-mediated hippocampal effects. This article reviews the mechanisms and the evidence for stress-buffering interventions including adaptogens and behavioral strategies.