2026-02-19
Lion's Mane and Cognitive Function: Mechanisms, Human Evidence, and Protocol
Lion's Mane mushroom stimulates nerve growth factor production and has shown cognitive benefits in small randomized trials in older adults, with preclinical evidence stronger than human data.
2026-02-19
Resveratrol and Memory Retention: Evidence from a 26-Week Randomized Trial in Older Adults
Witte et al. (2014) found statistically significant memory improvements in adults 50–75 taking 200 mg/day resveratrol for 26 weeks, alongside improved hippocampal connectivity and glucose metabolism. Sample size was small (n=46) and findings require replication.
2026-02-16
Phosphatidylcholine: Liver Health, Cognitive Aging, and Choline Adequacy
Phosphatidylcholine is the dominant structural phospholipid in cell membranes and a major dietary choline source. It supports liver fat export, membrane integrity, and acetylcholine synthesis. Most adults are choline-insufficient; supplementation has meaningful implications for liver and brain aging.
2026-01-27
Alpha-GPC: Bioavailable Choline, Cognitive Aging, and Acetylcholine Support
Alpha-GPC is the most bioavailable choline supplement and crosses the blood-brain barrier effectively. Clinical trials show improvements in cognitive function in older adults with mild cognitive impairment. Often preferred over citicoline for acute cognitive enhancement.
2026-01-24
Citicoline (CDP-Choline): Acetylcholine Synthesis, Brain Energy, and Stroke Recovery
Citicoline provides both choline (for acetylcholine) and cytidine (converted to uridine, a phosphatidylcholine precursor). Evidence supports cognitive protection after stroke and modest improvements in age-related cognitive decline.