2026-02-24
Chronic Allergic Inflammation in Aging: Mechanisms and Evidence-Based Management
Allergic inflammation can worsen with immune senescence, contributing to systemic inflammatory load. This article covers the evidence for dietary and supplement interventions that modulate allergic response without the side effects of antihistamines.
2026-02-24
Gut Barrier Integrity in Aging: Intestinal Permeability, Inflammaging, and Support
Age-related increases in intestinal permeability ("leaky gut") allow bacterial products including lipopolysaccharide (LPS) to enter systemic circulation, driving chronic low-grade inflammation associated with multiple aging-related conditions. Evidence-based interventions include dietary fiber, fermented foods, and specific probiotics — though research on reversing permeability changes in older humans is in early stages.
2026-02-24
Inflammaging: Chronic Low-Grade Inflammation in Aging, Causes, and Intervention Evidence
Inflammaging — the chronic low-grade inflammatory state that accumulates with age — is now recognized as a driver of virtually every major age-related disease. Senescent cells, gut dysbiosis, and visceral fat are the primary sources. Targeted interventions address the root causes, not just the biomarkers.
2026-02-24
Menopause and Perimenopause: Supplement Evidence for Hot Flashes, Bone Loss, and Cognitive Symptoms
The menopausal transition accelerates bone loss, cognitive change, sleep disruption, and cardiovascular risk. Supplement evidence varies sharply: isoflavones have modest hot flash data; calcium and vitamin D are well-supported for bone; magnesium helps sleep. Black cohosh is used widely but evidence is mixed.
2026-02-21
Gut Microbiome and Probiotics in Aging: Diversity Decline, Leaky Gut, and Evidence-Based Interventions
The gut microbiome undergoes progressive diversity loss with age — a pattern linked to increased intestinal permeability, systemic inflammation, and reduced short-chain fatty acid production. Dietary fiber, fermented foods, and targeted probiotics have the best evidence for reversing these changes.