2026-02-24
Alcohol, Aging, and Long-Term Health: What the Evidence Shows
Alcohol consumption interacts with aging biology in complex ways. This article covers the liver, brain, cardiovascular, and cancer evidence, plus what nutritional strategies can mitigate harm.
2026-02-24
Circadian Rhythm Disruption in Aging: Mechanisms, Health Consequences, and Restoration
Circadian clocks govern virtually every physiological process — metabolism, immune function, DNA repair, and hormone secretion follow 24-hour rhythms entrained by light. With aging, the circadian system weakens: clock gene amplitude declines, light sensitivity decreases, and circadian outputs desynchronize. Strengthening circadian inputs through light exposure, meal timing, and physical activity has evidence-based effects on sleep, metabolic health, and biological aging.
2026-02-24
Estrogen, Menopause, and Aging: Hormonal Mechanisms, Health Implications, and Protocol
Menopause-associated estrogen decline drives accelerated changes in cardiovascular risk, bone density, cognitive function, and metabolic health. Menopausal hormone therapy (MHT) has RCT and observational evidence supporting benefits for symptomatic relief and bone protection; cardiovascular and breast cancer risks depend on timing, type, and route of administration.
2026-02-24
GLP-1 Agonists and Aging: Metabolic Benefits, Cardiovascular Evidence, and Longevity Implications
GLP-1 receptor agonists like semaglutide have demonstrated cardiovascular and metabolic benefits beyond weight reduction. This review covers the mechanistic basis, major trial evidence, and the open questions about their role in longevity medicine.
2026-02-24
Grip Strength as a Longevity Biomarker: What It Predicts and How to Maintain It
Grip strength is a validated predictor of all-cause mortality, cardiovascular outcomes, and functional decline. This review covers the evidence base, what thresholds matter, and practical strategies to maintain grip and overall muscular capacity with age.