2026-02-23
Blood Sugar and Insulin Resistance: Supplement Protocol, Monitoring, and Evidence Summary
Insulin resistance precedes type 2 diabetes by years and independently drives cardiovascular risk, cognitive decline, and accelerated aging. Berberine, magnesium, alpha-lipoic acid, and chromium have the best evidence among supplements. This protocol integrates the strongest interventions with clear monitoring markers.
2026-02-19
Berberine for Metabolic Health: Evidence from Human Trials
Berberine activates AMPK through mild mitochondrial Complex I inhibition, producing improvements in glucose metabolism and modest weight loss in meta-analyses of clinical trials.
2026-02-19
Metabolic Syndrome: A Comprehensive Evidence-Based Protocol
Metabolic syndrome affects 1 in 3 adults and accelerates aging across every system. This protocol covers the interconnected drivers and the best-evidenced interventions for each component.
2026-02-17
Caloric Restriction Mimetics in 2025: Multi-Pathway Geroprotectors Under Clinical Evaluation
A 2025 Biogerontology review maps geroprotective compounds targeting AMPK, mTOR, and autophagy pathways. Most remain at biomarker endpoints; hard longevity data in humans is largely absent.
2026-02-14
Carnosine: Glycation Buffering, Brain Aging, and Carnosinase Variability
Carnosine is a dipeptide that buffers glycation and carbonyl stress, with additional evidence for neuroprotection. Oral carnosine is cleaved by carnosinase — tissue uptake varies significantly by carnosinase genotype, which affects individual response.