2026-02-18
CoQ10 and Mitochondrial Function: Age-Related Decline and Clinical Evidence
CoQ10 declines with age and statin exposure. Human evidence is strongest in heart failure and statin-associated muscle symptoms, while prevention use in healthy adults remains less certain.
2026-02-17
NAD+ Precursor Supplementation and Cognitive Fatigue: Mechanism and Human Evidence
NAD+ precursors reliably elevate blood NAD+ in humans and activate mitochondrial energy pathways. Whether this translates to clinically meaningful reductions in cognitive fatigue requires larger, longer trials.
2026-02-05
Mitochondrial Health Stack: CoQ10, PQQ, Carnitine, ALA, and Urolithin A — Synergies and Evidence
A comprehensive mitochondrial support protocol addresses electron transport (CoQ10), fatty acid transport (carnitine), biogenesis (PQQ, urolithin A), and antioxidant protection (ALA). Each supplement addresses a different node in mitochondrial biology. Stacking rationale is strong, though direct synergy evidence in humans is limited.
2026-02-03
Cognitive Enhancement Stacks: Lion's Mane vs Bacopa vs Citicoline vs PS vs ALCAR — Evidence Comparison
Five well-studied cognitive supplements work through distinct mechanisms. This article compares evidence quality, time-to-effect, practical considerations, and optimal combinations for lion's mane (NGF), bacopa (memory consolidation), citicoline (choline), phosphatidylserine (membrane), and acetyl-L-carnitine (mitochondrial).
2026-01-25
Acetyl-L-Carnitine (ALCAR) and Brain Aging: Evidence, Mechanism, and Nerve Health
Acetyl-L-carnitine (ALCAR) crosses the blood-brain barrier and supports acetylcholine synthesis and mitochondrial function in neurons. Evidence supports mild cognitive decline and peripheral neuropathy. ALCAR differs importantly from L-carnitine in CNS access.