2026-02-24
Senolytics and Cellular Senescence: Mechanisms, Mayo Clinic Evidence, and Clinical Status
Senolytics are drugs and compounds that selectively clear senescent cells, which accumulate with age and drive chronic inflammation. This review covers the mechanisms, the Mayo Clinic dasatinib+quercetin trials, fisetin evidence, and the current clinical status.
2026-02-24
Inflammaging: Chronic Low-Grade Inflammation in Aging, Causes, and Intervention Evidence
Inflammaging — the chronic low-grade inflammatory state that accumulates with age — is now recognized as a driver of virtually every major age-related disease. Senescent cells, gut dysbiosis, and visceral fat are the primary sources. Targeted interventions address the root causes, not just the biomarkers.
2026-02-19
Fisetin and Senolytic Research: Human Data, Protocol Context, and Limitations
Fisetin has a strong preclinical senolytic rationale, while human evidence remains early-stage with limited placebo-controlled outcome data.
2026-02-19
Polyphenol Protocols in Cognition Clinics: Clinical Context and Evidence Limits
Resveratrol, quercetin, and fisetin are used in some cognition-focused protocols, but human evidence is mixed and best interpreted as adjunctive support rather than primary therapy.
2026-02-18
Dasatinib and Quercetin for Senolytic Therapy: Mayo Clinic Phase 2 Trial Findings
A Mayo Clinic Phase 2 trial tested dasatinib plus quercetin in 60 older women with low bone density, finding improved bone formation markers. Dasatinib is an FDA-approved cancer drug requiring physician supervision.