2026-02-24
Senolytics and Cellular Senescence: Mechanisms, Mayo Clinic Evidence, and Clinical Status
Senolytics are drugs and compounds that selectively clear senescent cells, which accumulate with age and drive chronic inflammation. This review covers the mechanisms, the Mayo Clinic dasatinib+quercetin trials, fisetin evidence, and the current clinical status.
2026-02-24
Chronic Allergic Inflammation in Aging: Mechanisms and Evidence-Based Management
Allergic inflammation can worsen with immune senescence, contributing to systemic inflammatory load. This article covers the evidence for dietary and supplement interventions that modulate allergic response without the side effects of antihistamines.
2026-02-24
Polyphenol Stack Synergy: Quercetin, Resveratrol, Curcumin, and EGCG Combined Evidence
Quercetin, resveratrol, curcumin, and EGCG activate overlapping pathways — NRF2, SIRT1, AMPK, and NFkB inhibition. Stacking them is popular but evidence for synergistic human benefit is largely extrapolated from in vitro and animal models. This article assesses what stacking adds and what it does not.
2026-02-20
Gout and Uric Acid: Evidence-Based Management Beyond Medication
Gout is driven by uric acid crystal deposition, but diet, supplements, and lifestyle all modulate uric acid levels. Here is what the evidence shows.
2026-02-19
Fisetin and Senolytic Research: Human Data, Protocol Context, and Limitations
Fisetin has a strong preclinical senolytic rationale, while human evidence remains early-stage with limited placebo-controlled outcome data.