2026-02-18
Rapamycin in Older Adults: PEARL Trial Findings on Dose, Sex Differences, and Body Composition
The PEARL trial tested low-dose weekly rapamycin in healthy older adults. The primary endpoint — visceral fat reduction — was not met. Secondary analyses suggested lean tissue effects at higher doses in women, but these require confirmation in adequately powered trials.
2026-02-17
Caloric Restriction Mimetics in 2025: Multi-Pathway Geroprotectors Under Clinical Evaluation
A 2025 Biogerontology review maps geroprotective compounds targeting AMPK, mTOR, and autophagy pathways. Most remain at biomarker endpoints; hard longevity data in humans is largely absent.
2026-02-14
Supplement Cycling Protocols: Rapamycin, Senolytics, and Adaptogens — Evidence for Intermittent Use
Not all supplements should be taken daily. Rapamycin is typically dosed weekly to preserve mTOR signaling windows. Senolytics (dasatinib + quercetin, fisetin) are used in short intermittent bursts. Even some adaptogens are cycled to prevent tolerance. This article maps the rationale and evidence for each.
2026-02-05
mTOR, AMPK, and SIRT1: Longevity Pathway Switches and How Supplements Modulate Them
Three interlocked pathways — mTOR (growth/anabolism), AMPK (energy sensing), and SIRT1 (NAD-dependent deacetylase) — function as master longevity regulators. Supplements like rapamycin, berberine, and NMN modulate them through distinct entry points. Understanding the pathway logic prevents counterproductive stacking.
2026-02-01
Rapamycin and mTOR: Longevity Mechanism, PEARL Trial, and Low-Dose Protocol Risks
Rapamycin extends lifespan in every organism tested and the PEARL trial is the first human RCT for longevity use. mTOR inhibition reduces cellular senescence and improves immune function. Off-label use carries real risks that must be understood before consideration.