2026-02-24
SIRT3 and Mitochondrial Integrity: NAD-Dependent Deacetylase, Caloric Restriction Mimicry, and Activators
SIRT3 is the primary mitochondrial sirtuin — a NAD-dependent deacetylase that regulates ATP synthesis, ROS detoxification, and fatty acid oxidation. Its activity declines with age and NAD+ depletion. Activators include honokiol, urolithin A, and exercise, though human trial data is thin.
2026-02-21
Gut Microbiome and Probiotics in Aging: Diversity Decline, Leaky Gut, and Evidence-Based Interventions
The gut microbiome undergoes progressive diversity loss with age — a pattern linked to increased intestinal permeability, systemic inflammation, and reduced short-chain fatty acid production. Dietary fiber, fermented foods, and targeted probiotics have the best evidence for reversing these changes.
2026-02-18
CoQ10 and Mitochondrial Function: Age-Related Decline and Clinical Evidence
CoQ10 declines with age and statin exposure. Human evidence is strongest in heart failure and statin-associated muscle symptoms, while prevention use in healthy adults remains less certain.
2026-02-17
Caloric Restriction Mimetics in 2025: Multi-Pathway Geroprotectors Under Clinical Evaluation
A 2025 Biogerontology review maps geroprotective compounds targeting AMPK, mTOR, and autophagy pathways. Most remain at biomarker endpoints; hard longevity data in humans is largely absent.
2026-02-08
Mitochondria and Aging: Bioenergetics, ROS, Fission/Fusion Dynamics, and Intervention Targets
Mitochondrial dysfunction is a central hallmark of aging. ATP production efficiency declines, ROS production increases, and the balance of fission (fragmentation) and fusion (elongation) shifts unfavorably. This article explains the biology and maps interventions — from CoQ10 to urolithin A — to specific mitochondrial nodes.