2026-02-17
Caloric Restriction Mimetics in 2025: Multi-Pathway Geroprotectors Under Clinical Evaluation
A 2025 Biogerontology review maps geroprotective compounds targeting AMPK, mTOR, and autophagy pathways. Most remain at biomarker endpoints; hard longevity data in humans is largely absent.
2026-02-17
SIRT3 Activators in Early Clinical Development: Mitochondrial Targets for Aging
SIRT3 is a mitochondrial deacetylase linked to energy efficiency and oxidative stress resistance. Novel small-molecule SIRT3 activators are in preclinical development; human efficacy data does not yet exist.
2026-02-13
Alpha-Ketoglutarate and Aging: TET Enzyme Activity, Epigenetic Clocks, and Ca-AKG Trials
Alpha-ketoglutarate (AKG) is a TCA cycle intermediate that activates TET enzymes involved in DNA demethylation. The TRIIM-X trial using Ca-AKG reported a reduction in biological age markers. Evidence is preliminary but mechanistically credible.
2026-02-09
Calcium Alpha-Ketoglutarate and Epigenetic Aging: Biological Age Reduction Evidence
Calcium alpha-ketoglutarate (Ca-AKG) is an intermediate in the Krebs cycle and an alpha-ketoglutarate-dependent dioxygenase co-factor critical for epigenetic regulation. A clinical trial showed an 8-year reduction in biological age by DNA methylation clock. Evidence is early but striking.
2026-02-09
Epigenetic Clocks and Biological Age: Horvath, GrimAge, DunedinPACE — What They Measure
Epigenetic clocks measure DNA methylation patterns that change predictably with age. Different clocks predict different endpoints — Horvath measures biological age, GrimAge predicts mortality, DunedinPACE measures aging speed. Understanding what they do and don't measure is essential before acting on results.